In 2006, he produced NIP (Nuvens de Interação Proteica [Protein Interaction Clouds]), an art-science experiment developed in the Zero Gravity project directed by the Brazilian astronaut Marcos Pontes during his stay on board the International Space Station. As an architect, he designed more than 300 buildings and directed various art-science projects and films, in addition to publishing the books Amazing Amazon – Evolutionary Aesthetics, in 1997, and A Eco e Tecnociência na Arte de José Wagner Garcia, organized by Lúcia Santaella, in 2013. His main current activity is architecture and art-science. In 1990, he started the concept of bioprogrammable art and architecture. He is the director of Noosfera Arquitetura.